1908 - Otis Turner's Dr. Jekyll and Mr. Hyde

The first film adaptation of R. L. Stevenson's Strange Case of Dr. Jekyll and Mr. Hyde was directed by American director, Otis Turner, on March 7, 1908 and produced by William N. Selig. The film maintained numerous plot differences as it was more directly an adaptation of George F. Fish and Luella Forepaugh's 1897 four-act stage play. This film, while today lost media, became the first American horror film as well as the standard for the plots of future Jekyll and Hyde adaptations.

 The film starred Hobart Bosworth as Dr. Henry Jekyll and Mr. Edward Hyde, and Betty Harte as a third main character. It had a sixteen minute runtime and was critically praised for it's transformation scene done in a singular shot without the use of special practical effects.

 Allegedly, this poster was advertising for the film as well, however I have only seen confirmation that the first image was advertising. This advert is potentially for Sidney Olcott's adaptation of the same year.